Analysis performed on 2024-09-30 10:31:42
| Initial | Filtered Out | Final | Blast | |
|---|---|---|---|---|
| Bacteria | 93268 | 1075 | 92193 | 100183 |
| Archaea | 6414 | 164 | 6250 | 6196 |
| Vertebrata | 1557 | 316 | 1241 | 463 |
| Mammals | 545 | 81 | 464 | 131 |
| Protein Length | Pathogenic Variants | Benign/Unknown Variants |
|---|---|---|
| 1512 | 15 | 1225 |
| Domains | |
|---|---|
| Current Study | 1, 154 | 694, 1007 |
| Guo et al (2010) | 1, 178 | 749, 805 | 822, 878 | 900, 956 |
| Ancient Domains | Modern Domains | All | Ratio | |
|---|---|---|---|---|
| Number of Residues | 1045 | 467 | 1512 | 2.237687 |
| Number of Variants | 838 | 402 | 1240 | 2.084577 |
| Number of Pathogenic Variants | 11 | 4 | 15 | 2.750000 |
| Number of Benign/Unknown Variants | 827 | 398 | 1225 | 2.077889 |
| Fisher exact test | 0.784986 |
The Fisher exact test was calculated using a contingency table with the number of pathogenic and benign/unknown variants in ancient and modern domains. The bottom left values.
| Ancient Domains | Modern Domains | All | Ratio | |
|---|---|---|---|---|
| Number of Residues | 1163 | 349 | 1512 | 3.332378 |
| Number of Variants | 923 | 317 | 1240 | 2.911672 |
| Number of Pathogenic Variants | 11 | 4 | 15 | 2.750000 |
| Number of Benign/Unknown Variants | 912 | 313 | 1225 | 2.913738 |
| Fisher exact test | 1.000000 |
The Fisher exact test was calculated using a contingency table with the number of pathogenic and benign/unknown variants in ancient and modern domains. The bottom left values.
| # of sites Ancient | # sites Modern | Mean Ancient (SD) | Mean Modern (SD) | Median Ancient | Median Modern | Mann-Whitney U | p-value | |
|---|---|---|---|---|---|---|---|---|
| Current Study | 1045 | 467 | 0.79 (0.01) | 0.70 (0.01) | 8.233e-01 | 6.963e-01 | 311494.50 | 3.86e-18 |
| Guo et al (2010) | 1163 | 349 | 0.78 (0.01) | 0.69 (0.01) | 8.127e-01 | 6.865e-01 | 259965.50 | 7.87e-16 |
The Mann-Whitney U test was calculated using the conservation scores of the amino acids in ancient and modern domains. The p-value is for the null hypothesis that the conservation scores in ancient domains are greater than in modern domains.